The G20 is committed to improved health and well-being and has created Development and Health Working Groups to focus on the task. Within the context of the Decade of Action for Agenda 2030, this Policy Brief reviews the current state of maternal, newborn, child and adolescent health and well-being (MNCAH&W) in G20 countries, examines how outcomes have been affected by the Covid-19 pandemic, and offers specific recommendations for how G20 countries can recover lost gains for this demographic. Recommendations are aligned with the current health priorities of G20 that emphasise prevention, preparedness and response to health emergencies, digital health innovation, and solutions to aid Universal Health Coverage and strengthening the global health architecture. It recommends that G20 countries increase their investments to improve MNCAH&W in order to recover from the Covid-19 pandemic and nurture the sustainable social and economic development of societies for present and future generations.